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Taking Zofran may increase that risk. The substance is metabolized in the liver, mainly via CYP3A, and in the intestinal wall. Biotransformation: Baclofen is metabolised to only a minor extent. Appropriate dose adjustment and frequent clinical monitoring are advised in case of mild to moderate impairment. This medicine may cause some people to become dizzy, drowsy, lightheaded, clumsy, unsteady, or less alert than they are normally. Do not use after the use by (expiry) date printed on the pack or if the packaging is torn or shows signs of tampering.

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